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Guido Tans Selected Research

Activated Protein C Resistance (APC Resistance)

9/2006Venous thrombosis and oral contraceptives: current status.
2/2006Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels.
5/2005Effect of oral contraceptives on the anticoagulant activity of protein S in plasma.
6/2004Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.
2/2004Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679.
2/2004Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial.
10/2003Endogenous factor V synthesis in megakaryocytes contributes negligibly to the platelet factor V pool.
8/2003Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women.
2/2003Changes of hemostatic variables during oral contraceptive use.
1/2003Acquired resistance to activated protein C in breast cancer patients.
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Guido Tans Research Topics

Disease

13Activated Protein C Resistance (APC Resistance)
09/2006 - 03/2002
7Venous Thrombosis (Deep-Vein Thrombosis)
12/2007 - 07/2002
4Thrombosis (Thrombus)
10/2011 - 02/2006
2Protein S Deficiency (Deficiency, Protein S)
02/2006 - 07/2002
2Neoplasms (Cancer)
02/2006 - 01/2003
1Inflammation (Inflammations)
02/2006
1Atherosclerosis
02/2006
1Hemorrhage
12/2003
1Thrombophilia
01/2003
1Neoplasm Metastasis (Metastasis)
01/2003
1Breast Neoplasms (Breast Cancer)
01/2003
1Protein C Deficiency
07/2002
1Venous Thromboembolism
07/2002

Drug/Important Bio-Agent (IBA)

9ThrombinFDA Link
12/2007 - 03/2002
9Protein CIBA
12/2007 - 07/2002
6Protein SIBA
09/2006 - 01/2003
5Prothrombin (Factor II)IBA
07/2011 - 07/2002
5factor V LeidenIBA
06/2004 - 07/2002
4Thromboplastin (Tissue Factor)IBA
07/2011 - 01/2003
4Oral ContraceptivesIBA
09/2006 - 07/2002
3AnticoagulantsIBA
02/2006 - 06/2004
3Factor V (Coagulation Factor V)IBA
06/2004 - 09/2002
2DesogestrelFDA LinkGeneric
09/2006 - 02/2004
2Levonorgestrel (Plan B)FDA LinkGeneric
09/2006 - 02/2004
1Blood Coagulation Factors (Coagulation Factor)IBA
10/2011
1estropipate (Ogen)FDA LinkGeneric
10/2011
1FibrinIBA
10/2011
1PhosphatidylserinesIBA
07/2011
1Progestins (Progestagens)IBA
09/2006
1GestodeneIBA
09/2006
1Hemostatics (Antihemorrhagics)IBA
09/2006
1lipoprotein-associated coagulation inhibitor (TFPI)IBA
02/2006
1Proteins (Proteins, Gene)FDA Link
02/2006
1Factor Xa (Coagulation Factor Xa)IBA
05/2005
1protein S HeerlenIBA
06/2004
1factor V CambridgeIBA
02/2004
1Protein Isoforms (Isoforms)IBA
09/2002
1AntithrombinsIBA
07/2002

Therapy/Procedure

1Lasers (Laser)
07/2011
1Hormone Replacement Therapy (Therapy, Hormone Replacement)
07/2002